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Anti-Inflammatory and Antipyretic Effects of Boldine
Backhouse N, Delporte C, Givernau M, Cassels BK, Valenzuela A, Speisky H.
Departamento de Quimica Farmacologica y Toxicologica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago.
Boldine, an antioxidant alkaloid isolated from Peumus boldus, exhibits a dose-dependent anti-inflammatory activity in the carrageenan-induced guinea pig paw edema test with an oral ED50 of 34 mg/kg. Boldine also reduces bacterial pyrogen-induced hyperthermia in rabbits to an extent which varied between 51% and 98% at a dose of 60 mg/kg p.o. In vitro studies carried out in rat aortal rings revealed that boldine is an effective inhibitor of prostaglandin biosynthesis, promoting 53% inhibition at 75 microM. The latter in vitro effect may be mechanistically linked to the anti-inflammatory and antipyretic effects of boldine exerted in vivo.
SOURCE: National Library of Medicine. Agents Actions. 1994 Oct;42(3-4):114-7. PMID: 7879695 [PubMed - indexed for MEDLINE]
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Anti-Inflammatory and Antipyretic Effects of Boldine
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