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Effect of Dry Boldo Extract on Oro-Cecal Intestinal Transit

Effect of a dry boldo extract on oro-cecal intestinal transit in healthy volunteers

Gotteland M, Espinoza J, Cassels B, Speisky H.

Unidad de Gastroenterologia, INTA, Santiago de Chile.

BACKGROUND: Boldo (Peumus boldus Molina) is a widely used medicinal plant. However, its physiological effects are not well known. Recent studies in animals showed that certain components of boldo relax smooth muscle and prolong intestinal transit.

AIM: To assess the effects of a dry boldo extract on oro-cecal transit time in normal humans.

SUBJECTS AND METHODS: Twelve volunteers received 2.5 g of a dry boldo extract or a placebo (glucose) during two successive periods of four days. On the fourth day, 20 g of lactulose were administered and breath hydrogen was collected every 15 min. Oro cecal-transit time was defined as the time in which breath hydrogen increased by 20 ppm over the fasting level.

RESULTS: Oro-cecal transit time was larger after dry boldo extract administration, compared to placebo (112.5 +/- 15.4 and 87 +/- 11.8 min respectively, paired t p < 0.05).

CONCLUSIONS: Dry boldo extract prolongs oro-cecal transit time, a possible explanation for its medicinal use.

SOURCE: National Library of Medicine. Rev Med Chil. 1995 Aug;123(8):955-60. PMID: 8657963 [PubMed - indexed for MEDLINE]

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Effect of Dry Boldo Extract on Oro-Cecal Intestinal Transit

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