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Marigold

Not to be confused with the more toxic tagetes species of marigolds popular in North American gardens, the officinalis species are native to Europe and parts of Asia. The annual herb grows to two feet in height and produces vivid orange to yellow flower heads similar to daisies. Calendula was so named by the ancient Romans who observed that the flower bloomed on the first day (Latin: kalends) of every month. Calendula, or marigold, has long been praised for its healing properties taken internally and externally. Today, it is more often used, topically, as a treatment for cuts, scrapes, sores, and burns. However, its anti-inflammatory and anti-viral actions may also be benefited by those who take teas and liquid or dried supplements containing calendula extract.
 
Browse Sections:
 Summary
 Other Names
 Description
 Traditional Internal Uses
 Traditional Topical Uses
 Indications
 Actions
 Constituents / Nutrients
 Pharmacological Summary
 Scientific Research / Actions
 Precautions / Contraindications
 Possible Side Effects
 Dosage
 Preparation
 References

Common Name
Marigold
 
Botanical Latin Name / Classification
Calendula officinalis
 
Parts Used
Flower petals, dried flowers, leaves
 
Other Names
Gold-Bloom, Marigold, Marybud, Pot Marigold, Caltha officinalis, Golds, Ruddes, Mary Gowles, Oculus Christi, Marygold, Fiore d'Ogni Mese, Solis Sponsa, Poor Man's Saffron, Calendula, and Holigold.

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Description
Native to Egypt and the Mediterranean, marigold, or calendula, is an attractive, yellow-flowering plant. Europeans have grown this plant in their gardens for centuries for use nutritionally and medicinally. A member of the aster family, calendula should not be confused with its close relative, the common garden marigold (Tagetes species), which produces similar blooms but is regarded as too toxic for human consumption. It is primarily the colorful flower petals that are used medicinally.

The name "calendula" refers to the plant's perceived tendency to bloom according to the calendar, on a monthly basis, as observed by Ancient Romans. Calendula has also been called "poor man's saffron," due to its ability to brighten up both the color and flavor of soups, rice, and chowders. In modern culinary practices, the colorful marigold petals are a popular garnish for salads.

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Traditional Internal Uses
Calendula flower was well known to the old herbalists as a garden flower that also could be used for culinary or healing practices. It has been cultivated in the kitchen garden for the flowers, which are dried for broth, and said to comfort the heart and spirits.

While Persians and Greeks garnished and flavored food with the flower petals, the Germans enhanced their soups and broths with the addition of marigold petals. This earned this special yellow flower the nickname of "pot marigold". Europeans have also long used marigold flower to impart both coloring and flavor to their culinary creations.

Medieval monks were known to use calendula for bowel problems, liver complaints, and insect or snake bites.

In Macer's 12th Century Herbal, it is stated that only to look on marigolds will draw evil humours out of the head and strengthen the eyesight. In 1699, calendula was cited as a specific remedy for headaches, jaundice, red eyes, tootheache and ague. Broths made from flowers and sugar were taken in the morning for trembling, the plague, and pestilence.

During the American Civil War, doctors on the battlefield used the flowers to hasten the healing of open wounds, promote blood clotting, cleanse the tissue, and to prevent infection. The practice continued by doctors during the first World War.

In modern herbalist prescriptions, the inflammation of a sore throat is believed to be soothed by gargling with an infusion prepared from dried calendula flowers. The German Commission E Monographs approve of using calendula tea for treating "inflammation of the oral and pharyngeal mucosa."

Taken internally, calendula is believed to help inflammatory digestive system problems, including gastritis, peptic ulcers, regional ileitis, and colitis. Its anti-fungal and anti-parasitic actions make it useful for ridding intestinal worms and such fungal infections as candidiasis.

Calendula has long been used for its detoxifying properties and may prove beneficial in the treatment of conditions characterized by fever and infection. The herb is also thought to possess a cleansing action benefitting both the liver and gallbladder.

If taken as a hot infusion, calendula promotes sweating, improves blood and lymphatic circulation, and in turn bolsters the body's natural capacity to expel toxins and waste.

Calendula, or marigold, may be particularly beneficial for women. Taken regularly, marigold tea can ease the pain of menstruation and provide a regulating effect on the female reproductive cycle. Additionally, calendula is thought to restore hormonal balance during menopause. Calendula, when combined with regular massage, may benefit cellulite, though this has not been scientifically validated.

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Traditional Topical Uses
Marigold or calendula flower has long been used in topical applications and baths for a variety of health conditions. Culpepper wrote of how it strengthened the heart, and was useful for small pox and measles. He also mentioned how calendula instantly eased swelling when the juice of marigold leaves were used in combination with vinegar in a bath.

Today, calendula is regarded as a natural remedy for many minor superficial injuries to the skin and soft tissue such as sunburns, cuts and bruises, and scrapes and scratches. Historically, this herb was used to treat a wide variety of ailments, such as fever, cancer, and skin infections. Contemporary herbalists now prescribe calendula, topically, in herbal or homeopathic form, for conditions like boils, rashes, sunburns, chapped hands, insect bites, and other instances of inflamed or damaged skin. Calendula-based creams, lotions, and ointments are still widely used in Europe to increase the healing time of various skin problems. Gradually, their presence in the North American market is expanding to include, pharmacies, health food stores, as well as the offices of many natural health practitioners.

The herb's primary active compounds responsible for its anti-inflammatory action include triterpenoids and flavonoids. The anti-inflammatory, anti-viral, antiseptic, and astringent properties of calendula flower petals are supported by in vitro and animal studies. Studies also support its potential immune-stimulating and wound-healing actions.

Calendula used topically may be helpful for:
  • Burns and sunburns: Because it can reduce inflammation and has antiseptic and astringent properties, calendula may help burns to heal more rapidly. Some herbalists insist that it is the most effective component in the herbal treatment of first-degree burns. It is for this reason that many creams and ointments formulated for sunburn contain calendula.
  • Athlete's foot: In laboratory studies, calendula has demonstrated anti-fungal properties. Because athlete's foot is, by nature, a fungal infection, it follows that calendula would be beneficial as part of a natural treatment.
  • Itching associated with insect bites and stings: Calendula's confirmed anti-inflammatory action means that it can reduce the swelling and potential itching associated with insect bites. The further benefits of preventing subsequent infection and hastening healing may be attributed to the anti-microbial and astringent actions of this special flower.
  • Canker sores: Gargling with a calendula solution may provide relief for those with these painful sores. The combined antiseptic and anti-inflammatory properties of marigold flower are thought to be responsible for easing the pain associated with these inflamed oral blisters.
  • Healing of cuts and scrapes: For many of the same reasons mentioned above, calendula is often recommended for cuts and scratches, helping the wound to heal more rapidly.

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Indications
Primary Indications: Skin Disorders, Cuts and Abrasions, Minor, Burns, Immunity / Immune Disorders

Secondary Indications: Gastrointestinal Disorders, Gastritis / Gastric Juices, Peptic Ulcer, Ulcers, Colitis, Yeast Infection (Candida Albicans), Worms, Ringworms, Tapeworms, Pinworms, Menstruation Problems, Menopause

Other Indications: Colon Disease, Eye Disorders, Gallbladder Disorders, Insect Bites and Bee Stings, Jaundice, Liver Disorders, Measles, Migraine Headache, Snake Bites, Tooth Decay (Cavities / Caries)

Primary Indications: Bruising, Swelling / Inflammation

Secondary Indications: Sore Throat

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Actions
Anti-Inflammatory, Antibacterial, Antifungal, Antiseptic, Antispasmodic, Antiviral, Astringent, Bile Flow / Bile Duct / Bile Stimulant, Bitter Tonic, Detoxifying, Diaphoretic, Estrogenic, Female Tonic, Healing, Immunoactive / Immunomodulatory / Immunostimulative, Menstrual Regulating, Stimulant

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Constituents / Nutrients
Flavonoids: Pharmacopoeial standard not less than 0.4% flavonoids.(G15 G28) Flavonol (isorhamnetin, quercetin) glycosides including isoquercitrin, narcissin, neohesperidoside, and rutin.(1)

Polysaccharides: Three polysaccharides PS-I, -II and -III have a (3)-beta-D-galactan backbone with short side chains at C-6, comprising alpha-araban-(3)-araban, alpha-L-rhamnan-(3)-araban or simple alpha-L-rhamnan moieties.(2)

Terpenoids: Many components, including alpha- and beta-amyrin, lupeol, longispinogenin, oleanolic acid, arnidiol, brein, calenduladiol, erythrodiol, faradiol, faradiol-3-myristic acid ester, faradiol-3-palmitic acid ester,(3) helantriols A1, B0, B1 and B2, lupeol, maniladiol, urs-12-en-3,16,21-triol, ursadiol; oleanolic acid saponins including calendulosides C-H;(4) campesterol, cholesterol, sitosterol, stigmasterol and taraxasterol (sterols).(5)

Volatile Oils: Terpenoid components include menthone, isomenthone, caryophyllene and an epoxide and ketone derivative, pedunculatine, alpha- and beta-ionone, a beta-ionone epoxide derivative, dihydro actinidiolide.(6)

Other Constituents: Bitter (loliolide),(7) arvoside A (sesquiterpene glycoside),(8) carotenoid pigments(9) and calendulin (gum).(9) 111

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Pharmacological Summary
Phytochemical studies have reported four main groups of constituents, for calendula, namely flavonoids, polysaccharides, volatile oil and triterpenes. The latter seems to represent the principal group, with many compounds isolated including pentacyclic alcohols, glycosides (saponins) and sterols. Animal studies have reported wound-healing and anti-inflammatory effects, supporting the traditional uses of calendula in various dermatological conditions. The anti-inflammatory effect is due to the triterpenoid constituents although flavonoids may contribute to the activity. The reputed antispasmodic effect may be attributable to the volatile oil fraction. In addition, immunostimulant activity has been reported for high mol ecular weight polysaccharide components. Despite the popularity of calendula in herbal preparations there is little substantial clinical evidence to support its use.

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Scientific Research and Pharmacologicial Actions
In Vitro and Animal Studies

Anti-inflammatory, antibacterial and antiviral activities have been reported for calendula.(10) Weak anti-inflammatory activity in rats (carrageenan-induced oedema) has been reported.(11,12) An aqueous ethanolic extract had mild dose-dependent action in the mouse croton oil test with 20% inhibition being reached at a dose of 1200 æg/ear, whereas a carbon dioxide extract exhibited 70% inhibition at the same concentration.(5,13) The activity was shown to be due to the triterpenoids, the most active being a monoester of faradiol. Further separation of the triterpenoids has shown that the three most active compounds in the croton oil mouse test are faradiol-3-myristic acid ester, faradiol-3-palmitic acid ester and 4-taraxosterol.(3)

A polysaccharide enriched extract showed strong concentration-dependent adhesive properties on porcine buccal membranes ex vivo.(14) Fluorescent labelled rhamnogalacturan indicated the presence of polysaccharide layers on buccal membranes, leading to the suggestion that irritated buccal membranes may be smoothed by mucilage.

The formation of new blood vessels is an essential part of the wound-healing process. Angiogenic activity has been shown for a freeze-dried aqueous extract of calendula utilising the chick chorioallantoic membrane (CAM) assay.(15) The number of microvessels in calendula-treated CAMs was significantly higher than in the control (p < 0.0001). Furthermore, calendula-treated CAMs were positive for the glycosaminoglycan hyaluronan (HA) associated with neovascularisation. The presence of HA was not demonstrated in control CAMs.

A combination of allantoin and calendula extract applied to surgically induced skin wounds in rats has been reported to stimulate physiological regeneration and epithelisation.(16) This effect was attributed to a more intensive metabolism of glycoproteins, nucleoproteins and collagen proteins during the regenerative period in the tissues.(16) Allantoin applied on its own was found to exert a much weaker action.(16)

A proprietary cream containing a combination of plant extracts, including calendula, has been reported to be effective in dextran and burn oedemas and in acute lymphoedema in rats. Activity against lymph oedema was primarily attributed to an enhancement of macrophage proteolytic activity.(17) Slight increases in foot oedema were attributed to a vasodilatory action.

The trichomonacidal activity of calendula has been associated with the essential oil terpenoid fraction.(6)An in vitro uterotonic effect has been described for calendula extract on rabbit and guinea-pig preparations.(18)

Immunostimulant activity, assayed using granulocyte and carbon clearance tests, of calendula extracts has been attributed to polysaccharide fractions of high molecular weight.(19) Polysaccharides PS-I, -II and -III have immunostimulant activity at concentrations of 10-5 to 10-6 mg/mL, stimulating phagocytosis of human granulocytes in vitro.(2) A dry 70% ethanolic extract was not directly mitogenic, and was inhibitory in the mitogen-induced lymphocyte assay, causing stimulation at concentrations of 0.1-10 æg/mL, and inhibition at higher concentrations.(20)

A 70% methanolic extract of calendula was successively extracted with ether, chloroform, ethyl acetate and n-butanol, leaving a residual aqueous extract. Each of the five extracts were concentrated and dissolved in 50% ethanol to produce 6% (w/v) solutions which were assessed for activity on liposomal lipid peroxidation induced by Fe2+ and ascorbic acid. The ether, butanol and water extracts showed antioxidant activity.(21)

The triterpenoid constituents of calendula are reported to be effective as spermicides and as antiblastocyst and abortion agents.

In vitro cytotoxic activity and in vivo antitumour activity (against mouse Ehrlich carcinoma) have been documented for calendula extracts.(7) The most active fraction in vivo (saponin-rich) was not the most active in vitro.(10)

A 70% aqueous ethanolic extract had marked antiviral activity against influenza virus and herpes simplex virus. A dichloromethane-methanol (1 : 1) extract exhibited potent anti-HIV activity in an in vitro MTT/tetrazolium-based assay.(22) Uninfected Molt-4 cells were completely protected for up to 24 hours from fusion and subsequent death caused by co-cultivation with persistently infected U-937/HIV-1 cells. The organic extract caused a significant concentration- and time-dependent reduction of HIV-1 reverse transcriptase.(22)

In a study in mice fed for three weeks with a diet containing either 0.1% or 0.4% of a calendula extract (containing 37% of esters of the carotenoid lutein), mammary tumour cells were infused into the mammary glands. Tumour latency increased, and tumour growth was inhibited in a dose-dependent manner by dietary lutein. In addition, dietary lutein was reported to enhance lymphocyte proliferation.(23)

Clinical Studies

A proprietary cream preparation containing several plant extracts, including calendula, has been reported to reduce pain associated with postmastectomy lymphoedema, although there was no significant clinical difference in the reduction of oedema between controls and experimental groups.(17) Calendula tincture 20% has been reported to be useful in the treatment of chronic suppurative otitis.(24) Calendula extracts are used to accelerate healing and to reduce inflammation.(9) Thirty patients with burns or scalds were treated three times daily with a hydrogel containing 10% aqueous ethanolic extract of calendula for 14 days in an open, uncontrolled, pilot study.(25) Improvement was noted for reddening, swelling, blistering, pain, soreness and heat sensitivity.

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Precautions / Contraindications
Calendula may cause an allergic reaction in sensitive individuals, especially those with an existing hypersensitivity to other members of the Asteraceae/Compositae.

Pregnancy and Lactation

Calendula is traditionally reputed to affect the menstrual cycle. An uterotonic effect (in vitro) has been reported, and the triterpenoid constituents are reported to be effective as spermatocides and as antiblastocyst and abortion agents. In view of the lack of toxicity data, the use of calendula is best avoided during pregnancy and lactation.

When treating any type of wound, remember that the most important thing you can do to prevent infection is to thoroughly clean the area before applying calendula ointment or any other type of herb or medicine.

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Interaction with Medications
None documented.

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Possible Side Effects
An aqueous extract of calendula had an LD50 of 375 mg/kg (intravenous administration) and an LD100 of 580 mg/kg (intraperitoneal administration) in mice.(G52) Aqueous ethanolic extracts (drug/extract ratio 1 : 1 and 0.5 : 1, 30% ethanol) had LD50 values of 45 mg/mouse (subcutaneous administration) and 526 mg/100 g in rat (intravenous administration). An aqueous extract was not toxic following chronic administration to mice. Six saponins at doses of 400 micrograms were non-mutagenic in the Ames test using Salmonella typhimurium TA98 with and without S9 activation mixture.(G52) In vitro cytotoxicity has been reported for calendula extracts.(10) Extracts have been reported to be non-carcinogenic in rats and hamsters.(G52)

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Dosage
Dried Florets: 1-4 g or by infusion three times daily.(G7)

Liquid Extract: 0.5-1.0 mL (1 : 1 in 40% alcohol) three times daily.(G7)

Calendula Tincture: (BPC 1934) 0.3-1.2 mL (1 : 5 in 90% alcohol) three times daily.(G7)

Dried Extract: Marigold (Calendula) capsules are generally available in strengths that range from 300 to 600 mg. Within herbal blends, quantities of marigold flower are significantly smaller. Typically, a capsule strength of 400 to 500 mg is recommended to be taken 3 times daily.

External Use Tincture-liquid extract (1 : 1) in 40% alcohol or tincture 1 : 5 in 90% alcohol. Apply to wounds as such and dilute 1 : 3 with water for compresses. Ointment 2.5%.(G52)

The German Commission E Monographs recommend the following dosages for liquid preparations / infusions:
  • 1-2 g per cup of water (150 mL) or 1-2 teaspoons (2-4 mL) tincture per 1/4-1/2 L water, or prepared in ointments equivalent to 2-5 g crude drug in 100 g ointment.
Guidelines For Specific Indications:
  • For burns (including sunburn), apply three times a day to affected area until healed.
  • For athletes foot, apply cream or lotion to affected area twice a day until clear.
  • For insect bites and stings, rub a small dab of cream into skin several times a day or as needed.
  • For canker sores, rinse mouth 1 tbsp. liquid extract mixed with 1/2 cup water or with cooled tea 3 times a day.
  • For cuts and scrapes, apply ointment or cream 3 times a day, bandaging lightly if necessary.


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Preparation
To make calendula tea, pour 1 cup of boiling water over 1/2 teaspoon of dried florets (flower tops) and steep for 10 minutes. Once cooled, use the tea as a mouthwash, gargle, or in a cooling compress for wounds.

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References
1. Vidal-Ollivier E et al. Flavonol glycosides from Calendula officinalis flowers. Planta Med 1989; 55: 73.
2. Varljen J et al. Structural analysis of a rhamnoarabinogalactan and arabinogalactans with immuno-stimulating activity from Calendula officinalis. Phytochemistry 1989; 28: 2379-2383.
3. Zitterl-Eglseer K et al. Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.). J Ethnopharmacol 1997; 57: 139-144.(PubMed)
4. Pizza C et al. Plant metabolites. Triterpenoid saponins from Calendula arvensis. J Nat Prod 1987; 50: 927-931.
5. Della Loggia R et al. The role of triterpenoids in the topical anti-inflammatory activity of Calendula officinalis flowers. Planta Med 1994; 60: 516-520.(PubMed)
6. Gracza L. Oxygen-containing terpene derivatives from Calendula officinalis. Planta Med 1987; 53: 227.
7. Willuhn G, Westhaus R-G. Loliolide (Calendin) from Calendula officinalis. Planta Med 1987; 53: 304.
8. Pizza C, de Tommasi N. Plants metabolites. A new sesquiterpene glycoside from Calendula arvensis. J Nat Prod 1987; 50: 784-789.
9. Fleischner AM. Plant extracts: To accelerate healing and reduce inflammation. Cosmet Toilet 1985; 100: 45.
10. Boucard-Maitre Y et al. Cytotoxic and antitumoral activity of Calendula officinalis extracts. Pharmazie 1988; 43: 220.(PubMed)
11. Peyroux J et al. Propri‚t‚s anti-oed‚mateuses et anti-hyperh‚miantes du Calendula officinalis L. Plant M‚d Phytoth‚r 1981; 15: 210-216.
12. Mascolo N et al. Biological screening of Italian medicinal plants for anti-inflammatory activity. Phytother Res 1987; 1: 28-31.
13. Della Loggia R et al. Topical anti-inflammatory activity of Calendula officinalis extracts. Planta Med 1990; 56: 658.
14. Schmidgall J et al. Evidence for bioadhesive effects of polysaccharides and polysaccharide-containing herbs in a ex vivo bioadhesion assay on buccal membranes. Planta Med 2000; 66: 48-53.(PubMed)
15. Patrick KFM et al. Induction of vascularisation by an aqueous extract of the flowers of Calendula officinalis L. the European marigold. Phytomedicine 1996; 3: 11-18.
16. Kioucek-Popova E et al. Influence of the physiological regeneration and epithelization using fractions isolated from Calendula officinalis. Acta Physiol Pharmacol Bulg 1982; 8: 63-67.(PubMed)
17. Casley-Smith JR, Casley-Smith JR. The effect of `Unguentum lymphaticum' on acute experimental lymphedema and other high-protein edemas. Lymphology 1983; 16: 150-156.(PubMed)
18. Shipochliev T. Extracts from a group of medicinal plants enhancing the uterine tonus. Vet Med Nauki 1981; 4: 94-98.
19. Wagner H et al. Immunostimulating polysaccharides (heteroglycans) of higher plants. Arzneimittel forschung 1985; 35: 1069.(PubMed)
20. Amirghofran Z et al. Evaluation of the immunomodulatory effects of five herbal plants. J Ethnopharmacol 2000; 72: 167-712.(PubMed)
21. Popovic M et al. Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. Part 1. Marigold extract-ciprofloxacin/pyralene. Oxidation Commun 1999; 22: 487-494.
22. Kalvatchev Z et al. Anti-HIV activity of extracts from Calendula officinalis flowers. Biomed Pharmacother 1997; 51: 176-180.(PubMed)
23. Chew BP et al. Effects of lutein from marigold extract on immunity and growth of mammary tumors in mice. Anticancer Res 1996; 16: 3689-3694.(PubMed)
24. Shaparenko BA. On use of medicinal plants for treatment of patients with chronic suppurative otitis. Zh Ushn Gorl Bolezn 1979; 39: 48-51.
25. Baranov von AP. Calendula - wie ist die wirksamkeit bei verbrennungen und verbrhungen?. Dtsch Apotheker Zeitung 1999; 139: 2135-2138.

Our thanks to the following information resources: MedicinesComplete.com, American Botanical Council (Herbalgram.org), WholehealthMD.com, Botanical.com, Vitacost.com, Purplesage.org, and Innvista.com.

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56 total products
Marigold   (Read all about Marigold.)

Botanical Latin Name: Calendula officinalis
Plant Part: Flower petals, dried flowers, leaves
Marigold - Health - Tutti Fruitti Tea (Loose)
Marigold - Health - Tutti Fruitti Tea (Loose)
4 oz / 114 g
A Candy-Like Caramel Flavor That Kids Love!

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Marigold - Health - Tutti Fruitti Tea (Loose)
Marigold - Health - Tutti Fruitti Tea (Loose)
8 oz / 227 g
A Candy-Like Caramel Flavor That Kids Love!

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Was: 14.77 US

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Marigold - Health - Tutti Fruitti Tea
Marigold - Health - Tutti Fruitti Tea
25 tea bags
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Marigold - Health - Tutti Fruitti Tea
Marigold - Health - Tutti Fruitti Tea
50 tea bags
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Marigold - Health - Angel Falls Mist Tea (Loose)
Marigold - Health - Angel Falls Mist Tea (Loose)
4 oz / 114 g
A Wildly Exotic Tea!

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Marigold - Health - Angel Falls Mist Tea (Loose)
Marigold - Health - Angel Falls Mist Tea (Loose)
8 oz / 227 g
A Wildly Exotic Tea!

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Marigold - Health - Angel Falls Mist Tea
Marigold - Health - Angel Falls Mist Tea
25 tea bags
A Wildly Exotic Tea!

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Marigold - Health - Angel Falls Mist Tea
Marigold - Health - Angel Falls Mist Tea
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A Wildly Exotic Tea!

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Marigold - Health - Apricot Supreme Tea (Loose)
Marigold - Health - Apricot Supreme Tea (Loose)
4 oz / 114 g
Wonderfully Refreshing!

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Marigold - Health - Apricot Supreme Tea (Loose)
Marigold - Health - Apricot Supreme Tea (Loose)
8 oz / 227 g
Wonderfully Refreshing!

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Marigold - Health - Apricot Supreme Tea
Marigold - Health - Apricot Supreme Tea
25 tea bags
Wonderfully Refreshing!

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Marigold - Health - Apricot Supreme Tea
Marigold - Health - Apricot Supreme Tea
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These statements have not been evaluated by the Food and Drug Administration (FDA). Products are intended to support general well being and are not intended to treat, diagnose, mitigate, prevent, or cure any condition or disease. If conditions persist, please seek advice from your medical doctor.



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