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MSM (Methyl-Sulfonyl-Methane)
Browse Sections:
 Summary
 Other Names
 Traditional Internal Uses
 Indications
 Actions
 Pharmacological Summary
 Research
 Interaction with Medications
 References

Common Name
MSM (Methyl-Sulfonyl-Methane)
 
Other Names
Crystalline Dimethylsulfoxide, DMS0, Dimethyl Sulfone, Sulfonybis Methane

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Traditional Internal Uses
MSM is used as an analgesic and anti-inflammatory agent in musculoskeletal pain, it may facilitate dose reductions in conventional analgesic drugs, including narcotics; as a sulfur source for general sulfur supplementation or for musculoskeletal tissue healing after injury; as an antihistamine agent in allergies; as an antihistamine agent in allergic asthma.

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Indications
Aging, Analgesia (Pain Relief), Arthritis, Constipation, Detox / Toxicity, Food Allergies / Sensitivities, Healthy Skin, Hair, and Nails, Macular Degeneration (AMD), Osteoarthritis, Rheumatoid Arthritis, Snoring

Joint Pain, Swelling / Inflammation

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Actions
Anti-Inflammatory

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Pharmacological Summary
MSM is a natural and very safe nutritional supplement that is achieving a lot notoriety because of the many types of pain and inflammatory conditions it is able to address successfully. It is found in most plant foods and in meats, as well as in the body. MSM is recognized as a safe and virtually side-effect-free remedy for addressing painful and inflamed conditions, including osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, chronic back pain, chronic headache (less likely to help migraine suffering per se), muscle pain, fibromyalgia, tendinitis, bursitis, carpal tunnel syndrome, TMJ, post-traumatic pain and inflammation, lupus, scleroderma, and interstitial cystitis. Not only is it an important factor in pain and inflammation management, MSM delivers significant help in managing allergies and allergy caused asthma.

MSM has repeatedly provided significant reduction or full elimination of suffering due to unrelenting pain and / or inflammatory conditions. MSM has been described as miraculous because in some cases it has over turned what seemed like hopeless intractable suffering without rescue. For the most part though, MSM serves the swelling legion of North Americans who use inordinate amounts of drug intervention to control the pain and inflammation of a host of conditions that fill our daily conversations.

MSM delivers chronic pain relief with a performance that is comparable to the standard array of drug analgesia, and in many cases out performing the drug approach. However, be aware that MSM does not work as fast as traditional drug analgesia, and decidedly is not for the quick fix. For many chronic sufferers though, who seek deliverance from drug toxicity they bear as an unwanted added burden, the MSM waiting period is refreshingly insignificant. Commonly, it is a mere one to three weeks for the onset MSM is thought to work along four lines. Firstly, MSM is able to block pain impulses without toxic harm to the body associated with traditional and narcotic analgesic drugs. MSM's is thought to block the non-myelinated nerve fibers, referred to as the C-fibers. It is along the C-fiber network of nerves that deep aching pain is conducted. MSM has proved itself in significant pain control in approximately 70 percent of cases, with minor to no benefit in the balance of cases. It is appreciated for its ability to allow the user to eliminate or significantly reduce the quantity and frequency of analgesic drugs.

There is also some indication that the pain controlling benefit partly stems from blocking the perception of pain in the brain, but without affecting cognitive or driving ability as seen with heavy narcotic use. Pain is also thought to be reduced in part by the anti-inflammatory action of MSM. It also blocks muscle spasms that can be a significant factor in neck and scalp related headaches, or the pain of neck whiplash or lower back spinal pain.

Secondly, MSM is thought to be a sulfur-donor to the many metabolic operations that depend on adequate daily sulfur supply, including healing processes. Sulfur is critical to the production of collagen, the chief constituent of all connective tissue in the body. Therefore, adequate sulfur supply is central to restoring or maintaining musculoskeletal structural integrity, and especially so after traumatic injury when collagen production increases.

Thirdly, MSM is thought to enhance the body's own anti-inflammatory control system. Chronic inflammation responds to MSM because, in some unexplained way, it drastically increases the effectiveness of cortisol. As we grow older, adrenal cortisol production to control inflammation may have waned enough that enhancing the body's sensitivity to a reduced supply of cortisol with MSM could pay great dividends.

And fourthly, MSM seems to accelerate healing with marked improvement, even in cases that had been resistant to other treatments. Regarding allergies, in The Miracle of MSM The Natural Solution for Pain, clinicians Stanley W. Jacob, MD and Ronald M. Lawrence, MD, PhD, writing out of extensive experience with MSM, state that the single most powerful benefit offered by MSM is its quick relief of the symptoms of common allergies, for most users. Often the relief comes in one or two days, even if the allergy is of long standing. They feel that the abatement of pollen allergies delivered by MSM is so profound that it may be the best remedy since the introduction of antihistamines decades ago. In fact, it is not unusual for MSM users to say that it is better than antihistamines, and revel in their deliverance from antihistamine drug use. And perhaps the most wonderful feature, it can be used in children, sparing them from an early encounter with bodily toxicity. Other allergies including sinusitis, food allergies, skin allergies, etc, may respond to MSM as well.

Allergic asthma is another condition that MSM can address, and in most cases it does so well. Those with allergic asthma should involve their physician in order to provide professional counseling on how to understand any gains and on medication changes that seem warranted. MSM may provide a major improvement in asthma management, including the attainment of greater forced expiration volume (FEV) and reduced cortisone requirements. With daily use, and with physician participation, MSM offers the hope of significant respiratory health enhancement.

Allergy symptoms arise due to some weakness in the immune system and due to inflammation. The action of MSM is observedto impact on these two domains, but the exact mechanism of how MSM reduces allergy symptoms is not fully understood.

In people without allergies, the immune system efficiently controls the threat of invading foreign particles like pollen, with a metered amount of histamine release. This efficiency delivers sufficient histamine in the invaded area to bring about a defense cascade of chemical events inside mucous membrane cells and ancillary immune cells that comfortably rids the body of the foreign invaders. It is a quiet battle, with efficient dispatch. In fact, these lucky people do not realize that their immune system is in high gear because they do not feel the battle that is taking place. However, an exaggerated release of histamine by an over excited immune system provoked by an invading foreign particle, creates an exaggerated defense response, which is felt as the symptoms of an allergy attack. It is an ugly battle, where friendly-fire from immune elements is afflicting self.

Exaggerated histamine levels enter the mucous membrane cells in the affected areas and cause inflammation, swelling, itching, mucus flows, and other symptoms of allergy. MSM does not inhibit the production of histamine from within the immune system, as do some anti-histamines, but it is thought to block histamine from entering the mucous membrane cells, thus preventing the exaggerated defense response with its unwanted symptoms.

In the case of allergic asthma, also called extrinsic asthma, restricted breathing occurs because an exaggerated histamine allergy response has involved the trachea and the bronchial air passage way with smooth muscle constriction, swelling of the bronchial membrane, and the formation of mucus plugs. All three of these conditions work against the free flow of air, thus the characteristic features of an asthmatic episode from restricted breathing and wheezing to full blown closure of the air passage way. MSM blocks the excessive histamine involved in allergic asthma.

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Research
"Methylsulfonylmethane (MSM) in Osteoarthritis of the Knee"

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Precautions / Contraindications
None documented.

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Interaction with Medications
After many years of clinical use, MSM has not been associated with adversely interacting with prescribed medications.

DMSO has been found to counteract platelet aggregation. MSM as a derivative has not been so studied but there is indication that it also will present a blood thinning effect. Those using coumadin or other blood thinning medication, including other natural blood thinning products like high doses of garlic, salmon oil, grape seed extract, and high doses of vitamin E, may be at risk of bleeding problems if using high doses of MSM.

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Possible Side Effects
None documented.

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References
Jacob, Stanley W., Lawrence, Ronald M., Zucker, Martin, The Miracle of MSM The Natural Solution For Pain, GP Putnam's Sons, New York, 1999

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1 product
MSM (Methyl-Sulfonyl-Methane) - Health - Respira Tonic
MSM (Methyl-Sulfonyl-Methane) - Health - Respira Tonic
500 ml

42.36 US
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These statements have not been evaluated by the Food and Drug Administration (FDA). Products are intended to support general well being and are not intended to treat, diagnose, mitigate, prevent, or cure any condition or disease. If conditions persist, please seek advice from your medical doctor.



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