| Sect. I | General Principles | 1 |
| Introduction | 1 |
| 1 | Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination | 3 |
| 2 | Pharmacodynamics: Mechanisms of Drug Action and the Relationship Between Drug Concentration and Effect | 31 |
| 3 | Principles of Therapeutics | 45 |
| 4 | Principles of Toxicology and Treatment of Poisoning | 67 |
| 5 | Gene Therapy | 81 |
| Sect. II | Drugs Acting at Synaptic and Neuroeffector Junctional Sites | 113 |
| 6 | Neurotransmission: The Autonomic and Somatic Motor Nervous Systems | 115 |
| 7 | Muscarinic Receptor Agonists and Antagonists | 155 |
| 8 | Anticholinesterase Agents | 175 |
| 9 | Agents Acting at the Neuromuscular Junction and Autonomic Ganglia | 193 |
| 10 | Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists | 215 |
| 11 | 5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists | 269 |
| Sect. III | Drugs Acting on the Central Nervous System | 291 |
| 12 | Neurotransmission and the Central Nervous System | 293 |
| 13 | History and Principles of Anesthesiology | 321 |
| 14 | General Anesthetics | 337 |
| 15 | Local Anesthetics | 367 |
| 16 | Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium | 385 |
| 17 | Hypnotics and Sedatives | 399 |
| 18 | Ethanol | 429 |
| 19 | Drugs and the Treatment of Psychiatric Disorders: Depression and Anxiety Disorders | 447 |
| 20 | Drugs and the Treatment of Psychiatric Disorders: Psychosis and Mania | 485 |
| 21 | Drugs Effective in the Therapy of the Epilepsies | 521 |
| 22 | Treatment of Central Nervous System Degenerative Disorders | 549 |
| 23 | Opioid Analgesics | 569 |
| 24 | Drug Addiction and Drug Abuse | 621 |
| Sect. IV | Autacoids; Drug Therapy of Inflammation | 643 |
| Introduction | 643 |
| 25 | Histamine, Bradykinin, and their Antagonists | 645 |
| 26 | Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor | 669 |
| 27 | Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout | 687 |
| 28 | Drugs Used in the Treatment of Asthma | 733 |
| Sect. V | Drugs Affecting Renal and Cardiovascular Function | 755 |
| 29 | Diuretics | 757 |
| 30 | Vasopressin and Other Agents Affecting the Renal Conservation of Water | 789 |
| 31 | Renin and Angiotensin | 809 |
| 32 | Drugs Used for the Treatment of Myocardial Ischemia | 843 |
| 33 | Antihypertensive Agents and the Drug Therapy of Hypertension | 871 |
| 34 | Pharmacological Treatment of Heart Failure | 901 |
| 35 | Antiarrhythmic Drugs | 933 |
| 36 | Drug Therapy for Hypercholesterolemia and Dyslipidemia | 971 |
| Sect. VI | Drugs Affecting Gastrointestinal Function | 1003 |
| 37 | Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesophageal Reflux Disease | 1005 |
| 38 | Prokinetic Agents, Antiemetics, and Agents Used in Irritable Bowel Syndrome | 1021 |
| 39 | Agents Used for Diarrhea, Constipation, and Inflammatory Bowel Disease; Agents Used for Biliary and Pancreatic Disease | 1037 |
| Sect. VII | Chemotherapy of Parasitic Infections | 1059 |
| Introduction | 1059 |
| 40 | Drugs Used in the Chemotherapy of Protozoal Infections: Malaria | 1069 |
| 41 | Drugs Used in the Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections | 1097 |
| 42 | Drugs Used in the Chemotherapy of Helminthiasis | 1121 |
| Sect. VIII | Chemotherapy of Microbial Diseases | 1141 |
| 43 | Antimicrobial Agents: General Considerations | 1143 |
| 44 | Antimicrobial Agents: Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections | 1171 |
| 45 | Antimicrobial Agents: Penicillins, Cephalosporins, and Other [beta]-Lactam Antibiotics | 1189 |
| 46 | Antimicrobial Agents: The Aminoglycosides | 1219 |
| 47 | Antimicrobial Agents: Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents | 1239 |
| 48 | Antimicrobial Agents: Drugs Used in the Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy | 1273 |
| 49 | Antimicrobial Agents: Antifungal Agents | 1295 |
| 50 | Antimicrobial Agents: Antiviral Agents (Nonretroviral) | 1313 |
| 51 | Antimicrobial Agents: Antiretroviral Agents | 1349 |
| Sect. IX | Chemotherapy of Neoplastic Diseases | 1381 |
| Introduction | 1381 |
| 52 | Antineoplastic Agents | 1389 |
| Sect. X | Drugs Used for Immunomodulation | 1461 |
| 53 | Immunomodulators: Immunosuppressive Agents, Tolerogens, and Immunostimulants | 1463 |
| Sect. XI | Drugs Acting on the Blood and the Blood-Forming Organs | 1485 |
| 54 | Hematopoietic Agents: Growth Factors, Minerals, and Vitamins | 1487 |
| 55 | Anticoagulant, Thrombolytic, and Antiplatelet Drugs | 1519 |
| Sect. XII | Hormones and Hormone Antagonists | 1539 |
| 56 | Pituitary Hormones and Their Hypothalamic Releasing Factors | 1541 |
| 57 | Thyroid and Antithyroid Drugs | 1563 |
| 58 | Estrogens and Progestins | 1597 |
| 59 | Androgens | 1635 |
| 60 | Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones | 1649 |
| 61 | Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas | 1679 |
| 62 | Agents Affecting Calcification and Bone Turnover: Calcium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds | 1715 |
| Sect. XIII | The Vitamins | 1745 |
| Introduction | 1745 |
| 63 | Water-Soluble Vitamins: The Vitamin B Complex and Ascorbic Acid | 1753 |
| 64 | Fat-Soluble Vitamins: Vitamins A, K, and E | 1773 |
| Sect. XIV | Dermatology | 1793 |
| 65 | Dermatological Pharmacology | 1795 |
| Sect. XV | Ophthalmology | 1819 |
| 66 | Ocular Pharmacology | 1821 |
| Sect. XVI | Toxicology | 1849 |
| 67 | Heavy Metals and Heavy-Metals Antagonists | 1851 |
| 68 | Nonmetallic Environmental Toxicants: Air Pollutants, Solvents and Vapors, and Pesticides | 1877 |
| App. I | Principles of Prescription Order Writing and Patient Compliance | 1903 |
| App. II | Design and Optimization of Dosage Regimens: Pharmacokinetic Data | 1917 |
| Index | 2025 |
Format: Textbook Hardcover, 10th ed.,
