Home
Books
Sign In | View Cart Cart | Wish List | Help
ToysHealthPersonalAdultBaby
ToysHealthPersonalAdultBaby
Home & Garden
Checkout Now »
Cart Cart Cart
0 Items
Cart
100% Safe and Private!
Search     for:    
1-800-760-8783
Free Shipping! $100 minimum, US shipping address, TerraVita and Bianca Rosa products only
Home Page > Welcome!

St. John's Wort
Browse Sections:
 Summary
 Other Names
 Description
 Traditional Internal Uses
 Indications
 Pharmacological Summary
 Research
 Precautions / Contraindications
 Interaction with Medications
 Possible Side Effects
 Dosage
 References

Common Name
St. John's Wort
 
Botanical Latin Name / Classification
Hypericum perforatum
 
Parts Used
Aerial parts
 
Other Names
Hypericum, Goatweed, Klamath weed, Tipton weed

Browse Sections  |  View St. John's Wort products
 
Description
St. John's wort is an aromatic perennial herb that produces star-shaped golden yellow flower with five petals that secrete a red liquid when pinched. Originally, St. John's wort was native to Europe only, but now it can be found growing almost everywhere in the world.

This plant has been used for over 2,000 years. Ancient Greeks believed that its odor repelled evil spirits. Early Christians named the plant in honor of St. John the Baptist because they believed it released its blood-red oil on the 29th of August, the day the saint was beheaded.

Clinical trials support the assertion that St. John's wort is effective in maintaining normal sleep patterns and a healthy nervous system. It is also useful in the release of stress and frustration and in the re-balancing of moods. The efficacy of St. John's wort may be attributed to its effect on the immune system in addition to the effect of its active compounds.

Browse Sections  |  View St. John's Wort products
 
Traditional Internal Uses
St John's Wort is most commonly used for mild to moderate depression, anxiety, sleep disorders, some seasonal affective disorders.(1, 2, 4)

Browse Sections  |  View St. John's Wort products
 
Indications
Secondary Indications: Cold Sores

Primary Indications: Colitis, Depression Support

Secondary Indications: Ear Infection

Primary Indications: Eczema (Dermatitis)

Primary Indications: Immunity Deficiency, Infections

Primary Indications: Menopause, Sleep Support

Browse Sections  |  View St. John's Wort products
 
Pharmacological Summary
For many North Americans, it is simply amazing that a common ground covering plant like St. John's Wort could present an effective antidepressant option. Its very low incidence of troublesome side effects is all the more wonderful. As a plant, many different chemicals are present, providing a variable "pharmacy" of constituents that work together to synergize an overall neurotransmitter rebalancing, which is the general pharmaceutical approach to treating depression.

In one study, St. John's Wort was effective in 81.8% of patients evaluated for clinical mild to moderate depression, compared to 62.5% treated with Imipramine.(19) The overall accomplishment of St John's Wort for mild to moderate clinical depression is considered to be comparable to standard drug therapy with a considerably reduced report of adverse side effects. In general, it produces improvements in mood with a sense of well-being, and clinical improvement in feelings of sadness, hopelessness, helplessness, worthlessness, sleep initiation, and psychological anxiety, with headaches and fatigue occurring significantly less frequently. St. John's Wort may provide relief for those who suffer seasonal-related depression, and might address PMS-related depression.(20)

In a study in older volunteers, the proportion of REM sleep in the total sleep period was within the normal range of 20%, and after several weeks of treatment, St John's Wort at 300mg TID had no effect on sleep latency or the amount of REM sleep.(21)

In one study, moderate use of alcohol concurrent with treatment did not evidence an adverse interaction and the ability to drive in traffic, concurrent with St John's Wort therapy, was not impaired.(22)

Browse Sections  |  View St. John's Wort products
 
Research
"Herbs For Winter Woes?"


"Lose Weight Naturally"


"St. John's Wort and Alcohol Cravings"

Browse Sections  |  View St. John's Wort products
 
Precautions / Contraindications
Precautions

St John's Wort may increase anxiety.(8) St John's Wort may have the ability in the susceptible to induce serotonin syndrome, a condition consisting of extreme anxiety, confusion, nausea, hypertension, and tachycardia.(9)

St John's Wort may in some depressed people precipitate hypomania, mania, or an increased cycling of mood states, particularly people with occult bipolar disorder.(10)

Patients with uncontrolled high blood pressure, angina, or heart failure, should discuss with their physician the potential risk of a tyramine interaction with St John's Wort since it is thought to be a weak MAO inhibiter. Use caution with prescription drugs that are contraindicated with synthetic pharmaceutical MAO inhibitors, including L-dopa, 5-hydroxytryptophane, amphetamines, and over-thecounter cold and decongestion medication containing pseudoephedrine.

Hypericin is a phototoxic constituent in St John's Wort that is known to cause sunburn in animals grazing on St John's Wort. However, in the standardized extract with 0.3 percent hypericin, the recommended dose of 900 mg [300 mg TID] would deliver 2.7 mg of hypericin.

In steady-state oral administration tests running 7 days, 2.7 mg per day of hypericin did not provide evidence for a phototoxic potential in humans.(11) Insufficient data exists to support the use of St. John's Wort during pregnancy or during breast feeding.(12) Hypericin produces singlet oxygen and other excited state intermediates in vitro that indicate it should be a very efficient phototoxic agent in the eye lens. In a study on calf lens, hypericin did not damage lens protein in the dark, but under light conditions produced photo-polymerization.(13) Damage to alpha-crystallin could undermine the integrity of the lens directly by protein denaturation.

Those who are at risk of or have cataracts should supplement their diet with vitamins C and E, as well as lipoic acid, which are known to reduce the risk of cataracts. Another potent natural agent for combating cataract formation is lutein, which is specifically concentrated in the eye lens and the macula for preventing photon induced oxidation.

The American Society of Anesthesiologists caution that St John' Wort, as well as members of the ginseng group, can cause adverse interactions with anesthetics and should be discontinued at least one week before surgery. Cardiovascular collapse during anesthesia has been described in one otherwise healthy patient who had a 6-months history of using St John's Wort prior to surgery.(14)

Contraindications

St John's Wort should not be used with any other antidepressant medication, unless guided by a physician. The effect can be additive and the full outcome is unknown.

Browse Sections  |  View St. John's Wort products
 
Interaction with Medications
Concerning Monoamine Oxidase Inhibition:

St. John's Wort is understood to present only a weak monoamine oxidase inhibition.(15,16) The risk of interaction with tyramine is probably quite low. However, in at least one reported case, St John's Wort is suspected of interacting with tyramine in an incident of hypertensive crisis following consumption of foods containing tyramine.(17)

At the recommended daily amount of St. John's Wort, a blanket fear of a dietary tyramine interaction seems unwarranted. Interestingly, the long and widespread use in Germany and Europe of St John's Wort, where tyramine foods abound, has not given rise to a notable practical problem of tyramine interaction.(4)

Interactions In General:

Since St John's Wort first gained public awareness, numerous herbdrug interactions have been observed or suspected, frequently including cytochrome P450 interactions. The reader is referred to the Natural Medicines Comprehensive Database for interaction details and references.(18)

Browse Sections  |  View St. John's Wort products
 
Possible Side Effects
Side effects with St John's Wort are low in research literature and its extensive use in Germany has not resulted in published reports about serious drug interactions or toxicity after overdose.(4)

In a study with 3,250 patients, the most commonly noted side effects were gastrointestinal symptoms (0.6%), allergic reaction (0.5%), and fatigue (0.4%).(5)

Reports from other clinical studies include dizziness, nausea, restlessness, and dry mouth. Some older patients have complained of mild insomnia at 300 mg three times a day. Dosage reductions may be appropriate in some cases.(6)

The stressful sexual dysfunctions so frequently associated with all synthetic pharmaceutical antidepressants are much less frequently reported with St John's Wort.(7)

Browse Sections  |  View St. John's Wort products
 
Dosage
Recommended amount is 1 capsule 3 times daily or as directed by a physician.

Browse Sections  |  View St. John's Wort products
 
References
1. Linde, Klaus, et al, "St John's Wort for depression-an overview and meta-analysis of randomised clinical trials", British Medical Journal, 313:253-258, 1996
2. Hansgen, K.D., et al, "Multicenter double blind study examining the antidepressant effectiveness of the hypericum extract LI160", Journal of Geriatric Psychiatry and Neurology, 7 (suppl 1):s15-18, 1994
3. Volz, H.P., et al, St John's Wort extract (LI 160) in somatoform disorders: result of a placebo-controlled trial, Psychopharmacology (Berl), 164:294-300, 2002
4. DeSmet, Peter A. G. M., et al, St John's Wort as an antidepressant, British Medical Journal, 313:241-242, 1996
5. Woelk H., et al, "Benefits and risks of Hypericum extract LI-160: Drug monitoring study with 3250 patients", Journal of Geriatric Psychiatry and Neurology, 7 (suppl 1)):234-238, 1994
6. Harrer, G., et al, "Effectiveness and tolerance of the Hypericum extract LI-160 compared to Maprotiline: A multicenter double-blind study", Journal of Geriatric Psychiatry and Neurology, 7,(suppl 1):s24-s28, 1994
7. Hypericum Depression Trial Study Group, Effect of Hypericum perforatum (St John;s Wort) in major depression disorder:a randomized controlled trial, JAMA, 287:1807-1814, 2002
8. Beckman, S.E., et al, Consumer use of St John's Wort: A survey of effectiveness, safety, and tolerability, Pharmacotherapy, 20:568-574, 2000
9. Parker, V., et al, Adverse reactions to St John's Wort, Can J Psychiatry, 46:77-79, 2001
10. Nieren, A.A., et al, Mania associated with St John's Wort, Biol Psychiatry, Dec 15; 46(12):1707-1708, 1999
11. Schempp, C.M., et al, Effect of oral administration of Hypericum perforatum extract (St John's Wort) on skin erythemal and pigmentation induced by UVB, UVA, visible light and solar simulated radiation, Phytother Res, Feb; 17(2):141-146, 2003
12. Brown Donald J., "St John's Wort Clinical Monograph", Townsend Letters for Doctors and Patients, Oct., 1997
13. Schey, K.L., et al, Photooxidation of lens alpha-crystallin by hypericin(active ingredient in St John's Wort), Photochemistry and Photobiology, 72(2):200-203, 2000
14. Irefin, S., Sprung, J.A., A possible cause of cardiovascular collapse during anesthesia: long-term use of St John's Wort, J Clin Anesth, 12:498-499, 2000
15. Bladt S., Wagner H., "Inhibition of MAO by fractions and constituents of Hypericum extract", Journal of Geriatric Psychiatry and Neurology, 7 (suppl1):s57-s59, 1994
16. Miller, L.G.,Herbal Medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions, Arch Intern Med, 158:2200-2211, 1998
17. Patel, S, et al, Hypertensive crisis associated with St John's Wort, Am J Med, 112:507-508, 2002
18. Jellin, J.M., et al, Pharmacist's Letter/Prescriber's Letter Natural Medicines Comprehensive Database, 6th ed., Stockton, CA: Therapeutic Research Faculty, 2004
19. Vorbach E.-U., et al, "Effectiveness and tolerance of the Hypericum extract LI-160 in comparison with Imipramine: Randomized double-blind study with 135 patients", Journal of Geriatric Psychiatry and Neurology, 7 (suppl 1): s19-s23, 1994
20. Martinez, s., et al, "Hypericum in the treatment of Seasonal Affective Disorder", Journal of Geriatric Psychiatry and Neurology, 7 (suppl 1):s29-s33, 1994
21. Schulz, H., et al, "Effects of Hypricum extract on the Sleep EEG in older volunteers", Journal of Geriatric Psychiatry and Neurology, 7 (suppl 1): s39-s43, 1994
22. Hubner, W.-D., et al, "Hypericum treatment of Mild Depression with Somatic Symptoms", Journal of Geriatric Psychiatry and Neurology, 7 (suppl 1): s12-s14, 1994

Browse Sections  |  View St. John's Wort products
 


St. John's Wort - Herbal Plant Supplements

Click on any of the products below for detailed product information!
 

St. John's Wort Tea

St. John's Wort Tea

St. John's Wort Tea

St. John's Wort Tea

St. John's Wort Tea (Loose)

St. John's Wort Tea (Loose)

St. John's Wort Tea (Loose)

St. John's Wort Tea (Loose)

St. John's Wort - Glycerite Liquid Extract (1:5) - No Flavor

St. John's Wort - Glycerite Liquid Extract (1:5) - No Flavor

St. John's Wort - Glycerite Liquid Extract (1:5) - Strawberry Flavored

St. John's Wort - Glycerite Liquid Extract (1:5) - Strawberry Flavored

St. John's Wort - Salve Ointment

St. John's Wort - Salve Ointment

St. John's Wort Cream

St. John's Wort Cream

Anise Seed - Glycerite Liquid Extract (1:5) - No Flavor

Anise Seed - Glycerite Liquid Extract (1:5) - No Flavor

Anise Seed - Glycerite Liquid Extract (1:5) - Strawberry Flavored

Anise Seed - Glycerite Liquid Extract (1:5) - Strawberry Flavored

St. John's Wort - Glycerite Liquid Extract (1:5) - Chocolate Flavored

St. John's Wort - Glycerite Liquid Extract (1:5) - Chocolate Flavored

Anise Seed - Glycerite Liquid Extract (1:5) - Chocolate Flavored

Anise Seed - Glycerite Liquid Extract (1:5) - Chocolate Flavored

St. John's Wort - Glycerite Liquid Extract (1:5) - Vanilla Flavored

St. John's Wort - Glycerite Liquid Extract (1:5) - Vanilla Flavored

Anise Seed - Glycerite Liquid Extract (1:5) - Vanilla Flavored

Anise Seed - Glycerite Liquid Extract (1:5) - Vanilla Flavored

St. John's Wort - Glycerite Liquid Extract (1:5) - Mint Flavored

St. John's Wort - Glycerite Liquid Extract (1:5) - Mint Flavored

Anise Seed - Glycerite Liquid Extract (1:5) - Mint Flavored

Anise Seed - Glycerite Liquid Extract (1:5) - Mint Flavored

St. John's Wort Powder

St. John's Wort Powder

St. John's Wort Powder

St. John's Wort Powder

Depurative Formula Powder - Sarsaparilla, Borage, Soapwort and More

Depurative Formula Powder - Sarsaparilla, Borage, Soapwort and More

Depurative Formula Powder - Sarsaparilla, Borage, Soapwort and More

Depurative Formula Powder - Sarsaparilla, Borage, Soapwort and More

Depurative Formula Tea (Loose) - Sarsaparilla, Borage, Soapwort and More

Depurative Formula Tea (Loose) - Sarsaparilla, Borage, Soapwort and More

Depurative Formula Tea (Loose) - Sarsaparilla, Borage, Soapwort and More

Depurative Formula Tea (Loose) - Sarsaparilla, Borage, Soapwort and More

Depurative Formula Tea - Sarsaparilla, Borage, Soapwort and More

Depurative Formula Tea - Sarsaparilla, Borage, Soapwort and More

Depurative Formula Tea - Sarsaparilla, Borage, Soapwort and More

Depurative Formula Tea - Sarsaparilla, Borage, Soapwort and More

Kudzu and St. John's Wort Combination Powder

Kudzu and St. John's Wort Combination Powder

Kudzu and St. John's Wort Combination Powder

Kudzu and St. John's Wort Combination Powder

Kudzu and St. John's Wort Combination Tea

Kudzu and St. John's Wort Combination Tea

Kudzu and St. John's Wort Combination Tea

Kudzu and St. John's Wort Combination Tea

Extra Strength St. John's Wort 4:1 Extract Powder

Extra Strength St. John's Wort 4:1 Extract Powder

Extra Strength St. John's Wort 4:1 Extract Powder

Extra Strength St. John's Wort 4:1 Extract Powder

Extra Strength St. John's Wort (PE 0.3% Hypericin) Powder

Extra Strength St. John's Wort (PE 0.3% Hypericin) Powder

Extra Strength St. John's Wort (PE 0.3% Hypericin) Powder

Extra Strength St. John's Wort (PE 0.3% Hypericin) Powder

Extra Strength St. John's Wort (PE 0.3% Hypericin) Extract Cream

Extra Strength St. John's Wort (PE 0.3% Hypericin) Extract Cream

Extra Strength St. John's Wort (PE 0.3% Hypericin) Extract - Salve Ointment

Extra Strength St. John's Wort (PE 0.3% Hypericin) Extract - Salve Ointment

Extra Strength St. John's Wort 4:1 Extract Cream

Extra Strength St. John's Wort 4:1 Extract Cream

Extra Strength St. John's Wort 4:1 Extract - Salve Ointment

Extra Strength St. John's Wort 4:1 Extract - Salve Ointment

Backache Support Powder - Devil's Claw, Horsetail, White Willow and More

Backache Support Powder - Devil's Claw, Horsetail, White Willow and More

Backache Support Powder - Devil's Claw, Horsetail, White Willow and More

Backache Support Powder - Devil's Claw, Horsetail, White Willow and More

Backache Support Tea (Loose) - Devil's Claw, Horsetail, White Willow and More

Backache Support Tea (Loose) - Devil's Claw, Horsetail, White Willow and More

Backache Support Tea (Loose) - Devil's Claw, Horsetail, White Willow and More

Backache Support Tea (Loose) - Devil's Claw, Horsetail, White Willow and More

Backache Support Tea - Devil's Claw, Horsetail, White Willow and More

Backache Support Tea - Devil's Claw, Horsetail, White Willow and More

Backache Support Tea - Devil's Claw, Horsetail, White Willow and More

Backache Support Tea - Devil's Claw, Horsetail, White Willow and More

Depression Support Powder - St. John's Wort, Yohimbe and Pumpkin

Depression Support Powder - St. John's Wort, Yohimbe and Pumpkin

Depression Support Powder - St. John's Wort, Yohimbe and Pumpkin

Depression Support Powder - St. John's Wort, Yohimbe and Pumpkin

Depression Support Tea (Loose) - St. John's Wort, Yohimbe and Pumpkin

Depression Support Tea (Loose) - St. John's Wort, Yohimbe and Pumpkin

Depression Support Tea (Loose) - St. John's Wort, Yohimbe and Pumpkin

Depression Support Tea (Loose) - St. John's Wort, Yohimbe and Pumpkin

Depression Support Tea - St. John's Wort, Yohimbe and Pumpkin

Depression Support Tea - St. John's Wort, Yohimbe and Pumpkin

Depression Support Tea - St. John's Wort, Yohimbe and Pumpkin

Depression Support Tea - St. John's Wort, Yohimbe and Pumpkin

Kudzu and St. John's Wort Combination Tea (Loose)

Kudzu and St. John's Wort Combination Tea (Loose)

Kudzu and St. John's Wort Combination Tea (Loose)

Kudzu and St. John's Wort Combination Tea (Loose)

Kudzu and St. John's Wort Combination Glycerite Liquid Extract (1:5) - No Flavor

Kudzu and St. John's Wort Combination Glycerite Liquid Extract (1:5) - No Flavor

Kudzu and St. John's Wort Combination Glycerite Liquid Extract (1:5) - Strawberry Flavored

Kudzu and St. John's Wort Combination Glycerite Liquid Extract (1:5) - Strawberry Flavored

Kudzu and St. John's Wort Combination Glycerite Liquid Extract (1:5) - Vanilla Flavored

Kudzu and St. John's Wort Combination Glycerite Liquid Extract (1:5) - Vanilla Flavored

Kudzu and St. John's Wort Combination Glycerite Liquid Extract (1:5) - Chocolate Flavored

Kudzu and St. John's Wort Combination Glycerite Liquid Extract (1:5) - Chocolate Flavored

Kudzu and St. John's Wort Combination Glycerite Liquid Extract (1:5) - Mint Flavored

Kudzu and St. John's Wort Combination Glycerite Liquid Extract (1:5) - Mint Flavored

Backache Support Glycerite Liquid Extract (1:5) - No Flavor

Backache Support Glycerite Liquid Extract (1:5) - No Flavor

Backache Support Glycerite Liquid Extract (1:5) - Strawberry Flavored

Backache Support Glycerite Liquid Extract (1:5) - Strawberry Flavored

Backache Support Glycerite Liquid Extract (1:5) - Vanilla Flavored

Backache Support Glycerite Liquid Extract (1:5) - Vanilla Flavored

Backache Support Glycerite Liquid Extract (1:5) - Chocolate Flavored

Backache Support Glycerite Liquid Extract (1:5) - Chocolate Flavored

Backache Support Glycerite Liquid Extract (1:5) - Mint Flavored

Backache Support Glycerite Liquid Extract (1:5) - Mint Flavored

Depression Support Glycerite Liquid Extract (1:5) - No Flavor

Depression Support Glycerite Liquid Extract (1:5) - No Flavor

Depression Support Glycerite Liquid Extract (1:5) - Strawberry Flavored

Depression Support Glycerite Liquid Extract (1:5) - Strawberry Flavored

Depression Support Glycerite Liquid Extract (1:5) - Vanilla Flavored

Depression Support Glycerite Liquid Extract (1:5) - Vanilla Flavored

Depression Support Glycerite Liquid Extract (1:5) - Chocolate Flavored

Depression Support Glycerite Liquid Extract (1:5) - Chocolate Flavored

Depression Support Glycerite Liquid Extract (1:5) - Mint Flavored

Depression Support Glycerite Liquid Extract (1:5) - Mint Flavored

Backache Support Cream

Backache Support Cream


Sign In  |  Shipping  |  Returns  |  Privacy  |  About Us  |  Contact Us  |  1-800-760-8783
Copyright  2019  ZooScape.com ®